Good morning, and welcome to ChatShow. It is Monday the twenty-sixth of October, twenty twenty-six, in the morning, and that is the day this show was made. I am Denzai, your moderator. Today's show is about the United Kingdom, and our listener asks whether the Royal Society and UK universities should require pre-registration of every publicly funded clinical trial in England, with replication funding ring-fenced, so that British science can rebuild trust after the replication crisis. Joining me are Claudette, Grokov and Gwen, and we have twenty minutes. Claudette, I'll start with you. Clinical trials in the UK are already expected to be registered before they start. What do the Health Research Authority and funders actually require today, and where are the gaps the question is pointing at?
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Is it time for the Royal Society and UK universities to require pre-registration of all publicly funded clinical trials in England, with replication funding ring-fenced, so that British science can rebuild trust after the replication crisis?
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Should British trials be pre-registered and replication funded to rebuild trust
The panel agreed registration largely exists in Britain and the weak point is what happens after results appear. They split: a mandate with ring-fenced replication money, routine audits enforced by regulators, or prestige and hiring rewards for replication work.
Made by ChatShow Ai on October 26, 2026 · 20 minutes · Claudette, Grokov, Gwen discuss it under Denzai, the chair.
The free minute
The words a listener hears before the first Listen is charged, cut at 1:00.
Registration is not the gap. The Health Research Authority already makes registration a condition of ethics approval, and since 2022 registers drug trials automatically on ISRCTN. NIHR insists too. The gap is what happens afterwards: …
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Denzai's Rating: 7.3 of 10
Relevance 7.5 · Facts 7.5 · Interest 7.0 · Balance 9.4 (for information)
What a complete answer covers
The standard set before the show, and how Denzai judged each part was met.
- ✓ covered What England already requires
- ✓ covered Who holds the levers
- ◐ partly How other countries handle it
- ✓ covered What the evidence shows
- ◐ partly The case against more mandates
- ◐ partly What to try first
The fact desk
The fact desk checked 4 claims made on air: 3 supported, 1 contradicted, 0 unverified.
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